论文部分内容阅读
目的:观察泻心汤对表皮葡萄球菌所致兔胫骨慢性骨髓炎的治疗效果。方法:制备新西兰大白兔胫骨中段表皮葡萄球菌慢性骨髓炎感染模型,随机分成A、B、C三组各20只并分别给药,A组给予泻心汤煎剂10ml灌胃,每日两次;B组给予无菌泻心汤2ml局部注射,每日两次,C组给予生理盐水10ml灌胃,每日两次。观察给药后2W、4W、8W各组大白兔白细胞(WBC)、血沉(ESR)、C-反应蛋白(CRP),X线检测及HE染色等不同时相点的数据,比较泻心汤治疗兔胫骨慢性骨髓炎的抗感染效果。结果:A组、B组与C组之间有显著性差异(P<0.01);B组与A组有显著性差异,(P<0.05)。结论:泻心汤对表皮葡萄球菌所致兔胫骨慢性骨髓炎有明显的抑菌效果。
Objective: To observe the therapeutic effect of Xiexin Decoction on chronic osteomyelitis of tibia caused by Staphylococcus epidermidis in rabbits. Methods: Chronic osteomyelitis infection model of middle tibia of New Zealand white rabbits was prepared and randomly divided into three groups (A, B and C), 20 rats in each group. The rats in group A were given 10ml Xiexie decoction twice a day ; Group B was given sterile 2ml Xiexie Tang local injection twice a day, Group C given saline 10ml gavage twice daily. The WBC, ESR, CRP, X-ray and HE staining were observed at 2W, 4W and 8W after administration to compare the data of XieXinTang Anti-infection effect of tibia chronic osteomyelitis in rabbits. Results: There was significant difference between group A, group B and group C (P <0.01). There was significant difference between group B and group A (P <0.05). Conclusion: Xiexin Decoction has obvious antibacterial effect on chronic osteomyelitis caused by Staphylococcus epidermidis in rabbits.