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[目的 ]阐明丝虫与细菌感染对马来丝虫病急性淋巴管、淋巴结炎反复发作的作用。 [方法 ]1逐月访视病人 ,观察急性炎症发作季节消长。2在急性期患者的炎症部位取样作细菌培养 ;在急性发作过后不同时期作血清抗链球菌溶血素‘O’效价测定。3采取有效控制丝虫病传播或乙胺嗪治疗急性炎症史患者 ,观察急性发作的变化。 [结果 ]1发现急性发作高峰与蚊媒传播季节高峰相一致。2在急性发作患者中 ,97例作细菌培养 ,90例为阴性 ;2 5 5例作抗‘O’效价测定 ,初次发作和单纯炎症患者 94.1% (143/ 15 2 )未见效价增高。3在丝虫病传播得到有效控制后 ,急性炎症年发作率 ,初发和单纯炎症史患者迅速显著下降。4仅对急性炎症史者采取抗丝虫成虫治疗未能证实其减少炎症发作的效果。 [结论 ]在马来丝虫病流行区 ,急性淋巴管、淋巴结炎反复发作的主要原因是 ,丝虫病传播存在 ,患者受到重复感染 ,由感染期幼虫侵入人体后激发所致。
[Objective] To clarify the effect of filarial and bacterial infections on recurrent lymphangitic and lymphadenitis in malayian filariasis. [Method] A month-by-month visit to patients to observe the onset and decline of acute inflammatory episodes. 2 in the acute phase of inflammation in patients with sampling for bacterial culture; at different stages after the onset of acute anti-streptolysin ’O’ titer. 3 to take effective control of filariasis transmission or diethylcarbamazine treatment of acute inflammation in patients with acute exacerbation observed changes. [Results] 1 The peak of acute exacerbation was found to be consistent with the seasonal peak of mosquito-borne transmission. 2 Among 97 acute exacerbation patients, 97 were bacterial culture, 90 were negative. In 255 cases, the titer of anti ’O’ was not increased in 94.1% (143/152) of first episode and simple inflammation. 3 After the transmission of filariasis has been effectively controlled, the incidence of acute inflammation, the rate of first trimester and simple inflammation in patients with rapid decline significantly. 4 Treatment of filariasis adults with acute inflammation only failed to confirm its efficacy in reducing the onset of inflammation. [Conclusion] The main reason of recurrent acute lymphangitic and lymphadenitis in the endemic area of Malay Filariasis is that the transmission of filariasis exists, the patient is repeatedly infected and the larvae invade the human body after infection.