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目的评价睡眠剥夺条件下服用咖啡因对模拟飞行工作能力的影响。方法4名健康男性青年志愿者,连续3周模拟飞行试验,每周1次,每次试验时间从6:30至次日6:30实行24 h睡眠剥夺(在此期间不得睡眠或剧烈运动)过程中,于凌晨1:00分别服用咖啡因(200 mg)、苯丙胺(10 mg)或安慰剂(食用淀粉),并于服药前及服药后1、3h和5在飞行模拟器上检测模拟飞行工作能力。结果服用咖啡因后3和5 h的飞行成绩(正确保持率)分别为0.74和0.75,明显优于服用安慰剂组,咖啡因与苯丙胺两种药物之间的模拟飞行成绩差异无显著性意义。结论服用咖啡因200 mg对于24 h睡眠剥夺引起的模拟飞行能力下降具有明显的改善作用。
Objective To evaluate the effect of taking caffeine on simulated flight ability under sleep deprivation. METHODS: Four healthy male youth volunteers were enrolled in the study. They were given 3 consecutive weeks of simulated flight tests once a week for 24 hours of sleep deprivation from 6:30 to 6:30 the following day (no sleep or strenuous exercise during this period) During the study, caffeine (200 mg), amphetamine (10 mg) or placebo (food starch) were taken at 1:00 am and mock flights were tested on the flight simulator before taking and 1, 3 and 5 minutes after taking the drug Ability to work. Results The flight scores (correct retention rates) at 3 and 5 h after taking caffeine were 0.74 and 0.75, respectively, which were significantly better than taking placebo. Caffeine and amphetamine did not show significant difference in flight scores between the two drugs. Conclusion Caffeine 200 mg has a significant effect on reducing the simulated flight capacity caused by 24 h sleep deprivation.