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观察西替利嗪（cetirizine）对组险的阻断作用。分析pA2（拮抗指数），及对组胺致大鼠皮肤血管通透性增高和致豚鼠休克的影响。结果表明：西替利嗪为一竞争性H1受体拮抗剂．pA2为6．95，95％可信限为6．95±0．18；西替利嗪明显对抗组胺引起的皮肤血管通透性的增高，大中小剂量组的作用均优于扑尔敏；显著延长组胶静注致豚鼠呼吸加快的潜伏期，大中剂量组的作用优于扑尔敏，小剂量组与扑尔敏相当，且可完全阻止组胺林克的发生。结果提示：西替利嗪为一强效竞争性H1受体阻断剂。
To observe the blocking effect of cetirizine on group risk. Analysis of pA2 (antagonistic index), and histamine induced increased vascular permeability in rats and shock guinea pigs. The results show that: Cetirizine is a competitive H1 receptor antagonist. pA2 was 6.95, and 95% confidence interval was 6.95 ± 0.18. Cetirizine significantly antagonized the increase of skin vascular permeability caused by histamine. The effect of large, medium and small dosage groups was better than chlorpheniramine ; Significantly prolonged guinea pigs injected Guinea pig breathing to accelerate the incubation period, the role of large and medium dose group is better than chlorpheniramine, small dose group and chlorpheniramine quite, and can completely prevent the occurrence of histamine. The results suggest that: Cetirizine is a potent competitive H1 receptor blocker.