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目的研究白血病患者抗凝和纤溶系统的变化。方法采用单向免疫扩散法测定患者血清α１－抗胰蛋白酶（α１－ＡＴ）、α２－巨球蛋白（α２－Ｍ），血浆纤溶酶原（ＰＬＧ）；火箭免疫电泳法测血浆抗凝血酶Ⅲ抗原含量（ＡＴ－Ⅲ：Ａｇ）；刚果红显色法测纤溶酶（ＰＬ）活性；血凝法测纤维蛋白（原）降解产物（ＦＤＰ）；全自动生化分析仪测纤维蛋白原（ＦＧ）。结果α１－ＡＴ、α２－Ｍ、ＡＴ－Ⅲ：Ａｇ、ＰＬ活性、ＦＤＰ高于正常；血浆ＰＬＧ、ＦＧ降低；ＰＬ活性和ＡＴ－Ⅲ：ＡＧ的增高与出血的严重程度有关。结论白血病患者抗凝和纤溶活性增强；ＡＴ－Ⅲ：Ａｇ和ＰＬ活性的变化对病情观察有一定的意义。
Objective To study the changes of anticoagulation and fibrinolytic system in leukemia patients. Methods One-way immunodiffusion method was used to measure serum α1-antitrypsin (α1-AT), α2-macroglobulin (α2-M) and plasma plasminogen (PLG). Rocket immunoelectrophoresis was used to measure anticoagulation in plasma. Enzyme III antigen content (AT-III: Ag); Congo red color assay for determination of plasmin (PL) activity; hemagglutination assay for fibrin (raw) degradation products (FDP); automatic biochemical analyzer for fibrinogen (FG). Results α1-AT, α2-M, AT-III: Ag, PL activity, FDP were higher than normal; Plasma PLG, FG were decreased; PL activity and AT-III: AG increase were related to the severity of bleeding. Conclusion The anticoagulant and fibrinolytic activities of leukemia patients are enhanced. The changes of AT-III: Ag and PL activity have certain significance for the observation of the disease.