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外源性16S rRNA甲基化酶能介导细菌对多种氨基糖苷类抗菌药物高水平耐药,目前已发现10种外源性16S rRNA甲基化酶;该综述分析了外源性16S rRNA甲基化酶与两类内源性16S rRNA甲基化酶的联系,发现外源性16S rRNA甲基化酶可阻碍特定的内源性16S rRNA甲基化酶的甲基化作用,影响细菌的生长及对抗菌药物的敏感性,对基因环境的分析表明外源性16S rRNA甲基化酶基因常与其他耐药基因位于同一可移动基因元件上,耐药机制复杂,应继续监测外源性16S rRNA甲基化酶的流行情况,深入探讨其耐药机制的形成,以期早日改善临床致病菌耐药情况。
Exogenous 16S rRNA methylase mediates high levels of bacterial resistance to various aminoglycoside antibiotics. Ten exogenous 16S rRNA methylases have now been identified; this review summarizes exogenous 16S rRNA The association of methylases with two types of endogenous 16S rRNA methylase has revealed that exogenous 16S rRNA methylase can hinder the methylation of specific endogenous 16S rRNA methylase and can affect bacterial Of the growth and sensitivity to antibiotics, the analysis of the genetic environment shows that exogenous 16S rRNA methylase gene and other drug resistance genes are often located in the same mobile gene components, drug resistance mechanism is complex and should continue to monitor the exogenous Sex 16S rRNA methylase epidemic situation, in-depth study of the formation of its resistance mechanism, with a view to early improvement of clinical pathogenic bacteria resistance.