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目的：评价国产氟西汀的抗抑郁效果。方法：采用随机双盲治疗１８例抑郁障碍病人。氟西汀组１０例（男性５例，女性５例，年龄３９±ｓ１３ａ），给予氟西汀２０ｍｇ，ｐｏ，ｑｄ。阿米替林组８例（男性４例，女性４例，年龄４４±１４ａ），给予阿米替林７５ｍｇ，ｐｏ，ｂｉｄ。疗程６ｗｋ。结果：治疗期间各周末评定２组疗效相同，氟西汀组副作用明显低于阿米替林组（Ｐ＜０．０１）。结论：氟西汀抗抑郁作用肯定，疗效与阿米替林相当，副作用明显低于阿米替林。
Objective: To evaluate the antidepressant efficacy of domestic fluoxetine. Methods: Randomized double-blind treatment of 18 patients with depression. Fluoxetine group of 10 patients (5 males and 5 females, age 39 ± s13a), given fluoxetine 20mg, po, qd. Amitriptyline 8 patients (4 males, 4 females, age 44 ± 14a), given amitriptyline 75mg, po, bid. Treatment 6wk. Results: The curative effects of the two groups were the same during the treatment period, and the side effects of the fluoxetine group were significantly lower than those of the amitriptyline group (P <0.01). Conclusion: The antidepressant effect of fluoxetine is certain, the curative effect is equivalent to that of amitriptyline, the side effects are obviously lower than amitriptyline.