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目的探讨前列地尔联合黛力新治疗心脏X综合征的临床疗效。方法选择2015年4月—2016年12月收治的心脏X综合征患者90例,随机分为对照组和观察组各45例。两组均给予常规治疗,同时对照组给予前列地尔;观察组在对照组基础上给予黛力新,连续治疗8周。比较两组临床疗效,记录两组治疗前后典型心绞痛发作频率、发作时间,比较两组心电图疗效和平板运动试验结果。计数资料比较采用χ2检验,计量资料比较采用t检验,P<0.05为差异有统计学意义。结果治疗后观察组总有效率(93.3%)高于对照组(73.3%)(P<0.05);治疗后观察组心绞痛发作频率、发作持续时间[(3.2±0.5)次/周、(1.8±1.1)min/次]低于对照组[(8.7±0.8)次/周、(3.3±1.4)min/次](均P<0.01);观察组到达运动终点时间、至心绞痛发作的时间、至ST段下移1 mm的时间及总工作量[(8.2±1.1)、(7.1±1.9)、(6.0±1.4)min、(9.7±0.5)met’s]低于对照组[(8.7±1.2)、(7.8±1.2)、(6.9±2.1)min、(10.6±1.1)met’s](均P<0.05)。结论前列地尔联合黛力新治疗心脏X综合征效果显著,能有效改善患者心绞痛症状,增加运动耐受量,提高心脏储备能力。
Objective To investigate the clinical efficacy of alprostadil combined with Deanxit in the treatment of cardiac X syndrome. Methods Ninety patients with cardiac syndrome X admitted from April 2015 to December 2016 were randomly divided into control group and observation group of 45 cases. Both groups were given routine treatment, while the control group was given alprostadil. The observation group was given dexamethasone for 8 weeks on the basis of the control group. The clinical curative effect was compared between the two groups. The frequency of typical angina pectoris and the onset time of the two groups were recorded before and after treatment. The electrocardiogram curative effect and treadmill exercise test results were compared between the two groups. Counting data were compared using χ2 test, measurement data were compared using t test, P <0.05 for the difference was statistically significant. Results After treatment, the total effective rate (93.3%) in the observation group was significantly higher than that in the control group (73.3%) (P <0.05). After treatment, the frequency of angina pectoris, the duration of the attack were (3.2 ± 0.5) (P <0.01); the time to reach end of exercise, the time of angina pectoris onset to the end of angina pectoris in the observation group were significantly lower than those in the control group [(8.7 ± 0.8) ST-segment down 1 mm time and the total workload [(8.2 ± 1.1), (7.1 ± 1.9), (6.0 ± 1.4) min, (9.7 ± 0.5) met’s] was lower than the control group [8.7 ± 1.2 (7.8 ± 1.2), (6.9 ± 2.1) min, (10.6 ± 1.1) met’s] (all P <0.05). Conclusions Alprostadil combined with Deanxit has a significant effect on treating cardiac X syndrome, which can effectively improve the angina pectoris symptoms, increase exercise tolerance, and improve cardiac reserve capacity.