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目的评价肌氨肽苷联合注射用丹参对脑梗死患者的神经保护作用及其对相关生化指标的影响。方法 126例脑梗死患者随机分成观察组(肌氨肽苷联合注射用丹参)与对照组(肌氨肽苷)。于治疗前及治疗后2周测定血浆高敏C-反应蛋白(hs-CRP)、血清胆固醇(TC)、三酰甘油(TG)、高密度脂蛋白-胆固醇(HDL-C)、低密度脂蛋白-胆固醇(LDL-C)及纤维蛋白原(FIB)表达水平和神经功能缺损评分。结果二组治疗后血hs-CRP、TC、TG、LDL-C及FIB含量均明显降低(P<0.05),而HDL-C显著升高(P<0.05),但二组治疗后比较,各指标均差异有统计学意义(P<0.05)。同时二组治疗后神经功能缺损评分值均有所下降,以观察组为优(P<0.05)。结论肌氨肽苷、注射用丹参能减轻脑梗死患者的炎症反应,减轻对脑组织的损害,降低神经功能损伤,且肌氨肽苷联合注射用丹参疗效优于单独肌氨肽苷。
Objective To evaluate the neuroprotective effect of salvianolate combined with Salvia miltiorrhiza for cerebral infarction and its effect on related biochemical parameters. Methods A total of 126 patients with cerebral infarction were randomly divided into observation group (aminoglycoside and Salvia miltiorrhiza for injection) and control group (aminoglycoside). The levels of plasma hs-CRP, TC, TG, HDL-C, LDL-C, Cholesterol (LDL-C) and fibrinogen (FIB) expression levels and neurological deficit scores. Results The levels of hs-CRP, TC, TG, LDL-C and FIB in the two groups were significantly decreased (P <0.05) and HDL-C significantly increased after treatment There was significant difference between the indexes (P <0.05). At the same time, the score of neurological deficit decreased after treatment in both groups, which was better in the observation group (P <0.05). Conclusions Muscular aminoglycoside and Salvia miltiorrhiza can alleviate the inflammatory reaction in patients with cerebral infarction, reduce the damage to brain tissue and reduce the neurological damage. And the effect of muscular aminoglycoside combined with Salvia miltiorrhiza for injection is better than that of single aminoglycoside.