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大鼠食入大量的糖精发生膀胱癌的实验引起了人们对糖精与膀胱癌关系的兴趣。这些研究结果的意义及其与人的关系尚不明确。有几组研究人员已找到了可能因食用糖精引起人的膀胱癌发病率增高的证据。据调查,英、美两国膀胱癌死亡率并未因食用糖精而见增高,而且糖尿病患者表明,即使他们的糖精摄入量超过正常,但膀胱癌死亡率也未增高。Morgan和Jain采用信件询问的方式,直接调查了364名膀胱癌患者(男性240人)和470名对照患者(良性前列腺肥大310人及尿失禁的女性)。尽管回信率低(癌患者
Rat ingestion of large amounts of saccharin in the development of bladder cancer has led to an interest in the relationship between saccharin and bladder cancer. The significance of these findings and their relationship to people is unclear. Several groups of researchers have identified evidence that bladder cancer may be elevated in humans due to consumption of saccharin. According to the survey, the British and the United States did not show any increase in mortality from bladder cancer due to consumption of saccharin, and diabetic patients showed no increase in bladder cancer mortality even though their intake of saccharin exceeded their normal level. Morgan and Jain investigated 364 bladder cancer patients (240 males) and 470 control patients (310 benign prostatic hypertrophy and urinary incontinence) by mail inquiry. Despite the low response rate (cancer patients