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目的探讨脑梗死患者血同型半胱氨酸水平与颅内外动脉狭窄的相关性。方法以2011年6月至2012年8月我科收治的脑梗死患者92例为研究对象,住院期间均进行血Hcy与颅脑CTA检查。根据CTA结果分为颅内外动脉无狭窄组、颅内外动脉狭窄组;后者分为单纯颅内动脉狭窄组、单纯颅外动脉狭窄组和颅内外动脉均有狭窄组。将各组间血Hcy水平进行比较。根据血Hcy水平分为血Hcy正常组和高Hcy血症组,将两组间颅动脉狭窄例数进行比较。结果颅内外动脉均有狭窄组血Hcy水平显著高于无颅内外动脉狭窄组(P<0.05);单纯颅外动脉狭窄组血Hcy水平与单纯颅内动脉狭窄组差异无统计学意义(P>0.05)。与Hcy正常组相比,高Hcy血症组中颅内外动脉狭窄率增高(P<0.05)。结论血Hcy水平升高与颅内、外动脉粥样硬化性狭窄密切相关,是颅内外动脉狭窄病变的危险因素,对于颅内、颅外动脉的损伤无选择性。
Objective To investigate the correlation between plasma homocysteine levels and extracranial and extracranial arterial stenosis in patients with cerebral infarction. Methods A total of 92 patients with cerebral infarction admitted to our department from June 2011 to August 2012 were enrolled in this study. Blood Hcy and CTA were examined during hospitalization. According to CTA results were divided into intracranial and extra-arterial stenosis group, extracranial artery stenosis group; the latter is divided into simple intracranial artery stenosis group, extracranial artery stenosis group and extracranial artery stenosis group. Blood Hcy levels were compared between groups. Blood Hcy levels were divided into normal Hcy group and high Hcy hyperlipidemia group, the number of cases of stenosis between the two groups were compared. Results The level of Hcy in stenosis group was significantly higher than that in stenosis group (P <0.05). There was no significant difference in Hcy level between SLE group and SLE group (P> 0.05). Compared with the normal Hcy group, the rate of stenosis of intracranial and extracranial arteries increased in Hcy group (P <0.05). Conclusions The elevated blood levels of Hcy are closely related to the intracranial and extra-arterial atherosclerotic stenosis. It is a risk factor for intracranial and extracranial arterial stenosis and is not selective for intracranial and extracranial arterial injury.