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目的:评价液基细胞学(TCT)薄片制片对宫颈癌筛查的准确性。方法:2005年7月～2007年3月桐庐县妇幼保健院对1237例、1042例受检者分别采用TCT制片及传统宫颈细胞巴氏涂片法进行宫颈癌筛查。细胞学诊断均采用TBS分级系统,所有意义不明的不典型鳞状上皮(ASCUS)以上病变的受检者全部在阴道镜下活检、送病理检查(病检)。结果:TCT薄片法和传统巴氏涂片法对ASCUS以上病变的检出率分别为15.20%、4.89%,两者结果差异有显著性意义(P<0.01)。TCT检出低度鳞状上皮内病变(LSIL)、高度鳞状上皮内病变(HSIL)、鳞状细胞癌(SCC)与阴道镜活体组织检查(活检)阳性符合率分别为81.48%、92.59%、100.00%。传统宫颈巴氏涂片法检出LSIL、HSIL、SCC与阴道镜活检阳性符合率分别为53.33%、71.43%、100.00%。两种方法比较差异有显著性意义(P<0.01)。结论:TCT检查敏感性明显高于传统宫颈细胞涂片法,能大大提高检出率,尤其是对LSIL和HSIL的患者。
Objective: To evaluate the accuracy of liquid-based cytology (TCT) flake screening for cervical cancer screening. Methods: From July 2005 to March 2007 Tonglu Maternal and Child Health Hospital of 1237 cases, 1042 subjects were used TCT production and traditional cervical cell Pap smear cervical cancer screening. Cytological diagnosis using TBS grading system, all of the meaning of unknown atypical squamous epithelium (ASCUS) of the above lesions were all under biopsy colposcopy sent for pathological examination (disease examination). Results: The detection rates of the lesions above ASCUS by TCT and conventional Pap smears were 15.20% and 4.89%, respectively. The differences between the two methods were significant (P <0.01). The positive coincidence rates of LSIL, HSIL, SCC and colposcopic biopsy of TCT were 81.48% and 92.59% respectively, , 100.00%. Traditional cervical Pap smear LSIL, HSIL, SCC and colposcopy biopsy positive coincidence rates were 53.33%, 71.43%, 100.00%. There was significant difference between the two methods (P <0.01). Conclusion: The sensitivity of TCT is significantly higher than that of traditional cervical smear, which can greatly improve the detection rate, especially for patients with LSIL and HSIL.