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TAL-1基因易位是急性T淋巴细胞白血病中最常见的基因缺陷。为确定TAL-1基因易位与白血病的关系,观察了患者外周血和骨髓TAL-1基因的变化。结果:172例儿童患者中48例有TAL-l基因易位。在发生TAL-1基因缺陷的患者中,除白细胞计数及血红蛋白明显增高外,CD2阳性率明显增高(97.9％),CDl0阳性率则明显减少(12.5％)。观察5年存活率,TAL-1易位患者存活时间相对较长,但对患者预后的影响尚须进一步研究。
TAL-1 gene translocation is the most common genetic defect in acute T-lymphocytic leukemia. To determine the relationship between TAL-1 gene translocation and leukemia, changes in the peripheral blood and bone marrow TAL-1 gene were observed. RESULTS: Among the 172 children, 48 had TAL-1 gene translocation. In patients with TAL-1 gene defects, the positive rate of CD2 was significantly higher (97.9%), and the positive rate of CD10 was significantly decreased (12.5%), in addition to a significant increase in white blood cell count and hemoglobin. Observing the 5-year survival rate, the survival time of TAL-1 translocation patients is relatively long, but the impact on the prognosis of patients still needs further study.