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目的探讨血清铁蛋白与冠状动脉粥样硬化(CAD)病变程度及近期预后的关系。方法根据冠状动脉造影结果,将140例病人分组,66例诊断CAD,记录常见心血管危险因素,测定血清铁蛋白、C反应蛋白(CRP)及血脂。分析铁蛋白、CRP与常见心血管危险因素及它们的关系,并进行近期随访。结果CAD患者铁蛋白水平显著增高(P<0.01);多元线性回归分析,铁蛋白与TG(P=0.011)、性别(P=0.033)相关;二维logistic回归分析,CAD病变程度与铁蛋白(P=0.01)、年龄(P=0.001)、吸烟(P=0.012)相关;近期心脏事件患者铁蛋白水平显著增高(P<0.01)。结论在排除了炎症反应的影响下,血清铁蛋白与CAD病变程度独立相关,并对CAD患者近期预后有预测价值。
Objective To investigate the relationship between serum ferritin and the severity of coronary atherosclerosis (CAD) and its prognosis. Methods According to the results of coronary angiography, 140 patients were divided into groups, 66 patients were diagnosed with CAD, common cardiovascular risk factors were recorded, and serum ferritin, C-reactive protein (CRP) and serum lipids were measured. Analysis of ferritin, CRP and common cardiovascular risk factors and their relationship, and the recent follow-up. Results The level of ferritin in CAD patients was significantly higher than that in patients with CAD (P <0.01). The multivariate linear regression analysis showed that ferritin was associated with TG (P = 0.011) and gender (P = 0.033) P = 0.01), age (P = 0.001) and smoking (P = 0.012). The level of ferritin in patients with recent cardiac events was significantly higher (P <0.01). Conclusions Serum ferritin is independently associated with the degree of CAD lesions and the prognostic value of CAD in patients with CAD in the absence of the inflammatory response.