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目的对中晚期肝细胞癌治疗中肝动脉化疗栓塞联合伽玛刀序贯治疗的应用方法和临床疗效进行分析。方法选取南阳市肿瘤医院2010年3月至2012年5月收治中晚期肝细胞癌患者62例,随机分为两组,其中对照组30例接受单纯肝动脉化疗栓塞治疗,观察组32例接受肝动脉化疗栓塞与伽玛刀序贯联合治疗,对两组患者治疗后临床疗效进行对比。结果两组患者经治疗后,观察组总有效率显著高于对照组,甲胎蛋白水平恢复情况显著优于对照组,1年生存率显著高于对照组(P<0.05)。结论中晚期肝细胞癌治疗中,肝动脉化疗栓塞与伽玛刀序贯联合疗法具有显著临床疗效,可明显改善患者预后,显著延长患者生存期,值得在临床中推广。
Objective To evaluate the application and clinical efficacy of sequential hepatic artery chemoembolization combined with gamma knife in the treatment of advanced hepatocellular carcinoma. Methods 62 patients with advanced hepatocellular carcinoma who were treated in Nanyang Cancer Hospital from March 2010 to May 2012 were randomly divided into two groups, of which 30 patients in the control group received simple hepatic arterial chemoembolization and 32 patients in the observation group received hepatic Arterial chemoembolization and gamma knife sequential combination therapy, the clinical efficacy of two groups of patients after treatment were compared. Results After treatment, the total effective rate of the observation group was significantly higher than that of the control group. The recovery of alpha-fetoprotein was significantly better than that of the control group. The 1-year survival rate was significantly higher than that of the control group (P <0.05). Conclusions In the treatment of advanced hepatocellular carcinoma, transcatheter arterial chemoembolization and gamma knife sequential combined therapy have significant clinical efficacy, which can significantly improve the prognosis of patients and significantly prolong the survival of patients. It is worth to be popularized clinically.