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目的探讨热化疗及热碘油乳剂栓塞治疗原发性肝癌的临床效果。方法将55例经病理、影像学诊断、血清甲胎蛋白(AFP)检查确诊的原发性肝癌患者随机分为2组,加热组27例,采用热化疗(65℃)及热碘油(70℃)栓塞;常温组28例,采用常温(25.0±2.0)℃化疗药灌注及超液化碘油栓塞。所有病例术后定期做CT检查及AFP测定,观察对比肿瘤的客观疗效。结果 2组病例在近期有效率、AFP值变化及12个月、18个月生存率等方面比较差异有统计学意义(P<0.05)。肝功能及毒副反应比较差异无统计学意义(P>0.05)。结论加热化疗药及栓塞剂介入治疗原发性肝癌疗效肯定,优于常规TACE。
Objective To investigate the clinical effect of thermochemotherapy and thermal lipiodol emulsion embolization in the treatment of primary liver cancer. Methods Fifty-five patients with primary hepatocellular carcinoma diagnosed by pathology, imaging diagnosis and serum alpha-fetoprotein (AFP) were randomly divided into two groups. In the heating group, 27 patients were treated with thermal chemotherapy (65 ℃) and thermal lipiodol ℃) embolization; normal temperature group of 28 cases, using normal temperature (25.0 ± 2.0) ℃ chemotherapeutic drug infusion and ultra-liquefied iodized oil embolism. All cases were regularly done after CT examination and AFP determination of the objective observation of the efficacy of the tumor. Results The two groups of patients in the recent efficiency, AFP value changes and 12 months, 18 months survival rate and other aspects of the difference was statistically significant (P <0.05). There was no significant difference in liver function and toxicity (P> 0.05). Conclusion Heated chemotherapeutic drugs and embolic agents interventional treatment of primary liver cancer is positive, superior to conventional TACE.