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甾体激素受体在脑内的生理意义与机理所知尚少,本文应用受体放射分析技术与现代生物化学分析技术(如等电聚焦电泳,超离心技术)对鼠脑与人脑内的糖皮质激素受体(GR)、盐皮质激素受体(MR)、雌激素受体(ER)与孕激素受体(PR)的化学特性、含量检测及其临床意义作了比较系统的研究。尤其侧重在人脑肿瘤中GR,MRER和PR与脑水肿的关系和对肿瘤治疗及预后方面所起的作用。 概括地说,人脑与脑肿瘤中的GR与血管源性脑水肿的治疗和转归有密切关联;根据CT观察,进一步证实血管源性脑水肿主要原因是病变区血管的通透性呈病理性增高。糖皮质激素由于能降低和改善血管通透性,对脑水肿起到积极的治疗作用。颅内肿瘤中GR的多少与治疗因肿瘤引起的血管源性脑水肿的效果成正比。人脑与脑肿瘤,尤其是胶质细胞瘤中的MR推论与缺血性脑水肿的形成与发展有密切联系。而脑膜瘤象乳癌一样,瘤组织中含有ER及PR的阳性率分别为94％与82％;说明脑膜瘤是一种与雌激素关系密切的肿瘤,为今后对这类肿瘤的内分泌治疗开辟了道路。
The physiological significance and mechanism of steroid hormone receptors in the brain is still little known. In this paper, the receptor radiometric analysis techniques and modern biochemical analysis techniques (such as isoelectric focusing electrophoresis, ultracentrifugation technology) on the brain and human brain To investigate the chemical properties, content and clinical significance of glucocorticoid receptor (GR), mineralocorticoid receptor (MR), estrogen receptor (ER) and progesterone receptor (PR) Particular emphasis is placed on the relationship between GR, MRER and PR and brain edema in human brain tumors and their role in tumor treatment and prognosis. In summary, GR in human brain and brain tumors is closely related to the treatment and prognosis of vasogenic brain edema. According to CT observation, it is further confirmed that the main cause of vasogenic brain edema is the pathological change of vascular permeability Sex increased. Glucocorticoids play a positive therapeutic role in cerebral edema by reducing and improving vascular permeability. The amount of GR in an intracranial tumor is directly proportional to the effect of treatment on vasogenic brain edema caused by the tumor. MR reasoning in brain and brain tumors, especially in gliomas, is closely related to the formation and development of ischemic brain edema. The meningiomas, like breast cancer, the tumor tissue containing ER and PR-positive rates were 94% and 82%; meningioma is a estrogen-related tumor for the future of such tumors has opened up the endocrine therapy the way.