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目的探究护理干预在孕妇接种乙肝疫苗中的应用效果，以便为临床提供指导。方法选取接种乙肝疫苗的120例孕妇分成两组，每组60例，对照组采用常规护理，观察组在此基础上进行综合护理干预。结果护理后，观察组焦虑率及不良反应发生率明显低于对照组，且护理满意度明显高于对照组，<0.05。结论对接种乙肝疫苗孕妇进行综合护理干预措施，能够降低不良反应发生率，值得在临床上推广。“,”Objective To explore the nursing intervention in hepatitis B vaccination of pregnant women in the application results in order to provide clinical guidance. Methods 120 cases of hepatitis B vaccination of pregnant women into two groups of 60 patients in the control group received usual care, observation group comprehensive nursing intervention on this basis. Results After treatment, the observation group anxiety rate and incidence of adverse events was significantly lower than the control group, and significantly higher satisfaction with care, <0.05. Conclusion The hepatitis B vaccination of pregnant women comprehensive care interventions can reduce the incidence of adverse reactions, should be promoted in clinical practice.