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目的:研究降钙素原在产科重症感染治疗中应用的前瞻性意义。方法:选取我院收治的产科重症感染患者114例,并随机分为观察组与对照组,每组均为57例。对照组应用抗菌药物进行常规治疗,观察组在动态监测降钙素原(PCT)浓度变化的指导下行抗菌药物治疗。观察比较2组患者降钙素原(PCT)、超敏C反应蛋白(hs-CRP)与全血白细胞计数(WBC)变化情况、临床疗效、住院时间与抗菌药物应用时间。结果:观察组hs-CRP与WBC与对照组比较差别较小(P>0.05);观察组临床疗效较对照组高(P<0.05);观察组住院时间与抗菌药物应用时间均较对照组短(P<0.05)。结论:结合产科重症感染患者的降钙素原动态监测结果调整用药,可取得良好的临床疗效。
Objective: To investigate the prospective significance of procalcitonin in the treatment of severe obstetric infections. Methods: A total of 114 obstetric patients with severe obstructive diseases admitted to our hospital were randomly divided into observation group and control group, with 57 cases in each group. The control group was treated with antimicrobial drugs routinely. The observation group was treated with antimicrobial drugs under the guidance of the dynamic monitoring of the change of procalcitonin (PCT) concentration. The changes of procalcitonin (PCT), hs-CRP and WBC were compared between the two groups. The clinical efficacy, length of hospital stay and duration of antimicrobial treatment were compared. Results: The difference of hs-CRP and WBC between the observation group and the control group was less (P> 0.05), and the clinical curative effect in the observation group was higher than that in the control group (P <0.05). The hospitalization time and antibacterial application time in the observation group were shorter than those in the control group (P <0.05). Conclusion: In combination with dynamic monitoring of procalcitonin in obstetric patients with severe infections, the medication can be adjusted to achieve good clinical efficacy.