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目的:探讨老年急性冠脉综合征(ACS)患者血清γ-干扰素(IFN-γ)的水平含量与发病关系。方法:采用酶联免疫吸附法(ELISA)分别测定28例老年ACS患者、38例老年稳定型心绞痛(SA)患者及39例老年对照组(NC)的血清IFN-γ水平。结果:NC组与SA组比较IFN-γ含量差异无统计学意义(P>0.05),而ACS组IFN-γ含量低于NC组及SA组(P<0.001),差异有统计学意义。结论:老年ACS患者IFN-γ水平降低,出现机体免疫调节的失衡,可能对老年ACS的形成和发展产生了影响。IFN-γ水平可作为老年ACS严重程度的监测指标。
Objective: To investigate the relationship between serum interferon-γ (IFN-γ) level and the incidence of senile acute coronary syndrome (ACS). Methods: Serum IFN-γ levels were measured in 28 elderly ACS patients, 38 elderly patients with stable angina pectoris (SA) and 39 elderly controls (NC) by enzyme-linked immunosorbent assay (ELISA). Results: There was no significant difference in the IFN-γ levels between NC group and SA group (P> 0.05), but the level of IFN-γ in ACS group was lower than that in NC group and SA group (P <0.001). CONCLUSIONS: IFN-γ levels in elderly patients with ACS are reduced and there is an imbalance in immune regulation that may have an impact on the formation and development of elderly ACS. IFN-γ levels can be used as a monitoring indicator of the severity of ACS in the elderly.