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采用热疗过程中组织物性动态变化的光热模型,数值模拟了分别采用漫射光纤加入头和裸光纤加入头时的激光诱导肿瘤间质热疗(LITT)中热损伤体积的变化,并对实际漫射光纤加入头下发光强度不均匀的影响进行了分析。数值计算结果表明,通常情况下漫射光纤加入头产生的热损伤体积远大于裸光纤时的热损伤体积;裸光纤加入头产生的热损伤区域关于光纤端部不是球对称的,漫射光纤加入头产生的热损伤区域近似呈椭球形;漫射光纤产生的热损伤体积对加入头发光强度的非均匀性不太敏感。可见激光光纤加入头形式和发光特性对激光诱导肿瘤间质热疗具有重要的影响。
Using the photothermal model of dynamic changes of tissue properties during hyperthermia, the changes of thermal injury volume in laser-induced interstitial hyperthermia (LITT) were simulated numerically when diffuse fibers were added to the head and bare fibers respectively. The influence of the unevenness of the light intensity of the actual diffused fiber added to the head was analyzed. The results of numerical calculation show that the volume of thermal damage caused by the diffused fiber is much larger than that of the bare fiber. The thermal damage caused by adding the bare fiber is not spherical symmetric with respect to the fiber end. The thermal damage area generated by the head is approximately ellipsoidal; the volume of thermal damage caused by the diffused fiber is less sensitive to the inhomogeneity of the added light intensity of the hair. It can be seen that the form and luminescence characteristics of the laser fiber added to the head have an important influence on the laser induced tumor interstitial hyperthermia.