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目的了解新疆维吾尔族和汉族人群高尿酸血症患病的影响因素,为采取相应干预措施提供科学依据。方法采用以医院为基础的病例对照研究方法,对2012年2—12月在新疆医科大学第一附属医院住院的825例高尿酸血症患者和同期在该院体检的1 001名非高尿酸血症及痛风者进行问卷调查、体格检查和实验室检测。结果维吾尔族人群病例组吸烟、饮酒、肥胖、血脂紊乱、高胆固醇血症者的比例分别为51.35%、53.15%、48.20%、69.82%、24.32%,均高于对照组的24.24%、33.21%、36.27%、49.73%、18.67%,经常运动者的比例为20.00%,低于对照组的62.30%,差异均有统计学意义(均P<0.05);汉族人群病例组的吸烟、饮酒、经常吃肉、肥胖、血脂紊乱、高胆固醇血症、高血压、高血糖者的比例分别为55.91%、59.58%、83.99%、25.46%、76.64%、38.06%、21.26%、17.85%,均高于对照组的38.51%、47.07%、76.35%、7.88%、44.59%、23.42%、9.23%、24.77%,经常运动者的比例为23.36%,低于对照组的44.59%,差异均有统计学意义(均P<0.05);多因素条件logistic回归分析结果显示,吸烟、饮酒、肥胖、血脂紊乱是维吾尔族人群高尿酸血症患病的危险因素,经常运动是其保护因素;吸烟、肥胖、高血压、血脂紊乱、高胆固醇血症是汉族人群高尿酸血症患病的危险因素,经常运动是其保护因素。结论不同民族人群高尿酸血症患病的影响因素存在差异,其中是否吸烟、肥胖、血脂紊乱和经常运动是维吾尔族和汉族人群高尿酸血症患病的共同影响因素。
Objective To understand the influencing factors of the prevalence of hyperuricemia in Uygur and Han nationalities in Xinjiang and to provide a scientific basis for taking appropriate interventions. Methods A hospital-based case-control study was conducted in 825 patients with hyperuricemia who were hospitalized in the First Affiliated Hospital of Xinjiang Medical University from January to December in 2012 and 1,001 patients with non-hyperuricemia Symptoms and gout were surveyed, physical examination and laboratory tests. Results The proportion of smoking, drinking, obesity, dyslipidemia and hypercholesterolemia in the Uygur population were 51.35%, 53.15%, 48.20%, 69.82% and 24.32%, respectively, which were higher than that of the control group by 24.24% and 33.21% , 36.27%, 49.73% and 18.67%, respectively. The proportion of regular exercise was 20.00%, which was lower than that of control group (62.30%) (all P <0.05) The proportions of eating meat, obesity, dyslipidemia, hypercholesterolemia, hypertension and hyperglycemia were 55.91%, 59.58%, 83.99%, 25.46%, 76.64%, 38.06%, 21.26% and 17.85% In control group, the proportion of regular exercise was 38.51%, 47.07%, 76.35%, 7.88%, 44.59%, 23.42%, 9.23% and 24.77% respectively. The proportion of regular exercise was 23.36%, which was lower than that of control group (All P0.05) .Multivariate logistic regression analysis showed that smoking, alcohol drinking, obesity and dyslipidemia were risk factors of hyperuricemia in Uyghur population, and regular exercise was the protective factor. Smoking, obesity, high Blood pressure, dyslipidemia, hypercholesterolemia are hyperuricemia in the Han population Risk factors, regular exercise is a protective factor. Conclusions The influencing factors of hyperuricemia in different ethnic groups are different. Whether smoking, obesity, dyslipidemia and regular exercise are the common influencing factors of hyperuricemia in Uygur and Han population.