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目的:分析儿童急性髓系白血病(acute myeloid leukemia,AML)细胞遗传学特点。方法:回顾分析该院2010年1月~2014年6月初次诊断为急性髓系白血病的患儿63例。收集患儿治疗前骨髓标本,按照常规染色体培养方法进行,G显带法分析,核型异常按《人类细胞遗传学国际命名体制》(ISCN 2009)进行识别和描述。结果:63例患儿中男34例,女29例,年龄0.75~16岁,平均年龄13岁。异常核型患儿39例,发生率为63.93%。其中t(8;21)(q22;q22)的发生率最高,为31.15%,其次为t(15;17)(q22;q21),发生率为19.67%。数据结果未检测到11q23重排及单体型核型。结论:儿童AML患者细胞遗传学特点与成人不尽相同,提示两者的发病机制可能不同。中国儿童AML染色体核型发生率与国外报道不完全一致,提示细胞遗传学发生可能存在一定的种族或地域差异。
Objective: To analyze the cytogenetic characteristics of childhood acute myeloid leukemia (AML). Methods: A retrospective analysis of the hospital from January 2010 to June 2014 63 cases of children diagnosed with acute myeloid leukemia for the first time. Bone marrow samples collected from children before treatment were collected according to the conventional method of chromosome culture and analyzed by G-banding. The karyotypes were identified and described according to “The International Nomenclature of Human Cytogenetics” (ISCN 2009). Results: 63 cases of children with 34 males and 29 females, aged 0.75 to 16 years, mean age 13 years. 39 cases of abnormal karyotype children, the incidence was 63.93%. Among them, t (8; 21) (q22; q22) had the highest incidence of 31.15%, followed by t (15; 17) (q22; q21), the incidence was 19.67%. Data results did not detect 11q23 rearrangement and haplotype karyotype. Conclusion: The characteristics of cytogenetics in children with AML are different from those in adults, suggesting that the pathogenesis of both may be different. Chinese children with AML chromosome karyotype incidence and foreign reports are not exactly the same, suggesting that cytogenetic may be some race or geographical differences.