新生儿的恶性肝脏血管瘤

• 作 者: Nazir Z. Pervez S. 李丹
• 机 构: Section of Pediatric Surgery Department of Surgery Aga Khan University Stadium Road Karachi 74800 P
• 出 处: 世界核心医学期刊文摘(儿科学分册)
• 发表日期: 2006年05期
• 关键词: 新生儿 血管瘤 肝脏 肝血管肉瘤 组织学特征 肝活检 肺部转移 血管内皮瘤 药物治疗 转归

Malignant vascular tumors of the liver are rare in children, especially in neonates. We report two cases. One was initially diagnosed as infantile hemangioendothelioma. Rapid growth and appearance of pulmonary metastasis while on aggressive medical treatment suggested malignant transformation. The other neonate presented with intractable ascites and liver biopsy showed histological features of angiosarcoma. Ascites has rarely been reported as a presenting feature of angiosarcoma in literature. Both patients died. To date, surgery, chemotherapy, and radiotherapy have not improved the outcome of malignant vascular tumors of liver.

One of the initially diagnosed as infantile hemangioendothelioma. Rapid growth and appearance of pulmonary metastasis while on aggressive medical treatment suggested malignant transformation. The other neonate presented with intractable Ascites and liver biopsy showed histological features of angiosarcoma. Ascites has rarely been reported as a presenting feature of angiosarcoma in literature. Both patients died. To date, surgery, chemotherapy, and radiotherapy have not improved the outcome of malignant vascular tumors of liver.