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古洛糖酸伯喹(Primaguine Gulonate,PQG)iv 1—2mg/kg可使家兔异丙肾上腺素(IPA)加快心率的量一效曲线明显右移,并抑制最大效应。这种非竞争性对抗IPA加快心率的作用不可被阿托品对抗。PQG明显降低离体大鼠右心房肌的收缩幅度和窦性频率、明显降低离体兔左心房由肾上腺素诱发的异位节律点的自律性,提示古洛糖酸伯喹抗心律失常机制与其直接抑制心脏有关,也可能与共影响N~+、K~+和Ca~(++)转运有关。
Primaguine Gulonate (PQG) iv 1-2 mg / kg The dose-response curve of rabbit isoproterenol (IPA) to speed up the heart rate significantly shifted to the right and inhibited the maximum effect. This noncompetitive fight against IPA to speed up heart rate can not be antagonized by atropine. PQG significantly reduces the contractile amplitude and sinus frequency of the right atrial muscle in isolated rat and significantly reduces the autonomic activity of adrenaline-induced ectopic rhythm in the left atrium of isolated rabbit, suggesting that the anti-arrhythmic mechanism of primaquine guludine Direct inhibition of the heart, may also affect the total N ~ +, K ~ + and Ca ~ (++) transport related.