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[目的]探讨泌乳素受体及趋化因子和受体的变化与系统性红斑狼疮(SLE)疾病活动程度及相关性。[方法]2008～2010年,选取2006～2007年在山东省千佛山医院、山东大学齐鲁医院风湿免疫科门诊和住院的105例红斑性狼疮患者,检测血清胸腺和活化调节因子(TARC)、巨噬细胞炎性蛋白-lα(MIP-lα)、白细胞介素6(IL-6)、泌乳素受体(PRLP)水平;检测外周血CD4+T细胞表面趋化因子受体CCR4、CCR5的表达情况,检测血清ds-DNA抗体。同时检测50名健康体检者。[结果]PRLP、TARC、MIP-lα、IL-6、CCR4+CD4+T%、CCR5+CD4+T%,活动期病人均高于稳定期病人和正常对照组(P<0.01),稳定期病人高于正常对照组(P<0.01)。PRLP与MIP-lα、ds-DNA呈正相关(P<0.01),与CCR4+CD4+T%呈负相关(P<0.05),与CCR5+CD4+T%呈正相关(P<0.05)。[结论]PRLP与趋化因子及其受体间相互影响,它们的异常改变可能导致机体免疫紊乱,与SLE发病有关。
[Objective] To explore the changes of prolactin receptor, chemokines and receptors and the degree of activity of systemic lupus erythematosus (SLE). [Methods] From 2008 to 2010, 105 patients with lupus erythematosus were enrolled in the rheumatism clinic of Qifu Hospital of Shandong Province and Qilu Hospital of Shandong University from 2006 to 2007. The levels of serum thymic and activated regulatory factor (TARC) The levels of MIP-1α, IL-6 and PRLP in peripheral blood were measured. The expressions of CCR4 and CCR5 on peripheral blood CD4 + T cells Situation, detection of serum ds-DNA antibody. At the same time testing 50 healthy people. [Results] The levels of PRLP, TARC, MIP-1α, IL-6, CCR4 + CD4 + T%, CCR5 + CD4 + T% and active patients were higher than those in stable patients and normal controls (P <0.01) Patients were higher than the normal control group (P <0.01). PRLP was positively correlated with MIP-1αand ds-DNA (P <0.01), negatively correlated with CCR4 + CD4 + T (P <0.05), and positively correlated with CCR5 + CD4 + T (P <0.05). [Conclusion] PRLP interacts with chemokines and their receptors, and their abnormal changes may lead to immune disorders, which are related to the pathogenesis of SLE.