论文部分内容阅读
目的:探讨子宫动脉栓塞介入治疗(UAE)产后出血对产妇卵巢功能的影响。方法:选择32例难治性产后出血行子宫动脉栓塞介入治疗,获得成功止血的患者为介入组;随机选择同期分娩的正常产妇32例为对照组,均哺乳。比较2组产妇产后第1次月经后3~5天时血清卵泡刺激素(FSH)、黄体生成素(LH)、雌二醇(E2)水平,以及应用彩色多普勒测定卵巢动脉的阻力指数(RI)和搏动指数指数(PI)。结果:2组产妇于产后2~10个月后恢复正常月经,产后第1次月经后3~5天时FSH、LH及E2水平:介入组分别为7.19±0.67mIU/ml、6.93±0.47mIU/ml及E2 487.02±18.27pg/ml,对照组分别为7.07±0.71mIU/ml、6.77±0.95mIU/ml及478.03±17.65pg/ml,2组比较差异无显著性(P>0.05)。卵巢动脉的RI、PI值分别为:介入组0.61±0.38、1.06±0.54,对照组0.59±0.52、1.03±0.37,2组比较差异无显著性(P>0.05)。结论:应用双侧子宫动脉栓塞术治疗难治性产后出血是一种有效的治疗手段,对女性血清性激素及卵巢动脉血流动力学无明显影响。
Objective: To investigate the effect of uterine artery embolization (UAE) postpartum hemorrhage on maternal ovarian function. Methods: Thirty-two patients with refractory postpartum hemorrhage undergoing uterine arterial embolization were enrolled in this study. Patients with successful hemostasis were selected as the intervention group. Thirty-two normal pregnant women were randomly selected as control group. Serum follicle stimulating hormone (FSH), luteinizing hormone (LH) and estradiol (E2) levels were compared between the first postnatal menstruation and the second postnatal menstruation in two groups, and the resistance index of ovarian artery was measured by color Doppler RI) and pulsatility index (PI). Results: The two groups returned to normal menstruation after 2 ~ 10 months postpartum. The levels of FSH, LH and E2 after 3 ~ 5 days postpartum menstruation were 7.19 ± 0.67mIU / ml and 6.93 ± 0.47mIU / ml and E2 487.02 ± 18.27 pg / ml in the control group were 7.07 ± 0.71mIU / ml, 6.77 ± 0.95mIU / ml and 478.03 ± 17.65pg / ml, respectively. There was no significant difference between the two groups (P> 0.05). The RI and PI of ovarian artery were 0.61 ± 0.38 and 1.06 ± 0.54 in the intervention group, 0.59 ± 0.52 and 1.03 ± 0.37 in the control group, respectively. There was no significant difference between the two groups (P> 0.05). Conclusion: Bilateral uterine artery embolization for refractory postpartum hemorrhage is an effective treatment and has no significant effect on female sex hormone and ovarian hemodynamics.