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目的探讨硫酸特布他林与布地奈德联合平喘汤治疗发作期小儿支气管哮喘的临床疗效。方法选取2012年1月—2014年4月双流县中医医院收治的发作期小儿支气管哮喘患儿82例,随机分为治疗组(42例)与对照组(40例)。对照组患儿在西医常规治疗基础上予以硫酸特布他林联合布地奈德雾化吸入治疗,治疗组患儿在对照组基础上加用平喘汤治疗。观察两组患儿症状体征消失时间(平喘时间、哮鸣音消失时间)、实验室指标〔白细胞计数、血清总免疫球蛋白(Ig E)占预计值百分比及嗜酸粒细胞〕变化情况、临床疗效及不良反应发生情况。结果治疗组患儿白细胞计数及嗜酸粒细胞低于对照组,血清总Ig E占预计值百分比高于对照组,平喘时间短于对照组,差异有统计学意义(P<0.05),两组患儿哮鸣音消失时间比较,差异无统计学意义(P>0.05);两组患儿总有效率比较,差异无统计学意义(P>0.05);两组患儿不良反应发生率比较,差异无统计学意义(P>0.05)。结论硫酸特布他林与布地奈德联合平喘汤治疗发作期小儿支气管哮喘的临床疗效较好,可减轻患儿临床症状,且不良反应小。
Objective To investigate the clinical efficacy of terbutaline sulfate and budesonide combined with asthma in the treatment of infantile bronchial asthma. Methods Eighty-two children with bronchial asthma were randomly divided into treatment group (n = 42) and control group (n = 40), from January 2012 to April 2014 in Shuangliu Hospital of Traditional Chinese Medicine. Children in the control group were given inhalation of terbutaline sulfate combined with budesonide on the basis of routine treatment of western medicine. The children in the treatment group were treated with Pingchuan Decoction on the basis of the control group. The disappearance time of symptoms and signs (asthma relief time, wheezing disappearance time), laboratory indexes (white blood cell count, IgE in the predicted value and eosinophil count) in both groups were observed. Clinical efficacy and adverse reactions occurred. Results The white blood cell counts and eosinophils in the treatment group were lower than those in the control group. The percentage of total Ig E in the serum in the treatment group was higher than that in the control group, and the asthma relief time was shorter than that in the control group (P <0.05) There was no significant difference in the disappearance time of wheeze between the two groups (P> 0.05). There was no significant difference in the total effective rate between the two groups (P> 0.05). The incidence of adverse reactions in both groups was compared , The difference was not statistically significant (P> 0.05). Conclusion The combination of terbutaline sulphate and budesonide combined with asthma decoction in the treatment of infantile bronchial asthma has good clinical curative effect, which can relieve the clinical symptoms of children with little adverse reaction.