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以往认为血清碱性磷酸酶(AKP)与骨型AKP呈正相关,并以前者间接反映骨代谢状况,迄今尚无准确区分它们的特异手段。本文采用加热失活法和生化法测定Ⅱ型糖尿病肾病和非肾病患者的骨型AKP与血清AKP,还测定了其骨密度(BMD)和24小时尿羟脯氨酸(HOP)排泄量,以探讨糖尿病患者血清AKP、骨型AKP的关系及临床意义。 1 对象与方法 1.1 对象:(1)糖尿病Ⅱ型患者55例,均符合
In the past that the serum alkaline phosphatase (AKP) and bone type AKP was positively correlated, and the former indirectly reflect the status of bone metabolism, so far there is no exact distinction between their specific means. In this study, we measured the bone mineral density (BMD) and urinary hydroxyproline (HOP) excretion in patients with type 2 diabetic nephropathy and non-nephropathy by heat inactivation and biochemical methods. To investigate the relationship between serum AKP and bone type AKP in diabetic patients and its clinical significance. 1 objects and methods 1.1 objects: (1) 55 cases of type Ⅱ diabetes mellitus, are in line