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眼科使用噻吗心安后,即使其血浓度低至不能检出时,也可导致静息时和运动时的心率等心血管系统的变化。美国Leier等对此进行了研究,将20名健康受试者分成二组、分别使用0.5%噻吗心安顺丁烯二酸盐和人工泪液滴眼,1滴/次,每日2次,连续滴眼4周。最初滴眼后,10例中6例噻吗心安血浓度未能检出,其余4例各为0.5、0.8、1.5、2.0 ng/ml。连续使用4周后的血药浓度,有3例未能检出,其余7例在0.6～2.8 ng/ml。静息时或运动时的心率在首次滴眼后即减少。长期滴眼后,运动时的心率减少。即使连续滴眼4周后收
After the use of timolol in ophthalmology, changes in cardiovascular system, such as heart rate at rest and during exercise, can be caused even when the blood concentration is too low to detect. The United States Leier et al. Conducted a study of 20 healthy subjects were divided into two groups, respectively, 0.5% timolol maleate and artificial tears drop, 1 drop / time, twice daily, continuous Eye drops for 4 weeks. After the initial eye drops, 6 cases of thiazurin in 10 cases failed to detect the blood concentration, the remaining 4 cases were 0.5,0.8,1.5,2.0 ng / ml. After 4 weeks of continuous use of blood drug concentration, 3 cases failed to detect, and the remaining 7 cases ranged from 0.6 to 2.8 ng / ml. Heart rate at rest or during exercise decreases after the first eye drop. Long-term eye drops, heart rate decreased exercise. Even after 4 weeks of continuous eye drops received