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[目的]对比西洛他唑(培达)与银杏叶提取物治疗糖尿病周围神经病变(DNP)的临床疗效。[方法]将46例DNP患者随机分为培达组23例,银杏叶组23例。两组均经糖尿病教育、饮食控制、合理运动、降糖药物及胰岛素强化治疗,血糖基本平稳后,两组均予甲钴胺注射液500μg肌肉注射,每日1次,银杏叶组加用银杏叶提取物87.5mg加入生理盐水250mL内静滴每日1次;培达组加用西洛他唑0.2g加入生理盐水250mL内静滴每日1次,分别治疗15天。观察治疗后两组症状、体征并监测感觉神经和运动神经传导速度。[结果]治疗后两组症状均有改善,但培达组的效果更明显,两组间比较差异有显著性(P<0.05)。[结论]培达与银杏叶提取物治疗糖尿病周围神经病变均有临床疗效,但培达组优于银杏叶提取物组。
[Objective] To compare the clinical efficacy of cilostazol and ginkgo biloba extract in the treatment of diabetic peripheral neuropathy (DNP). [Methods] 46 patients with DNP were randomly divided into Peida group 23 cases, 23 cases of Ginkgo biloba group. Both groups were given diabetes mellitus, diet control, reasonable exercise, hypoglycemic drugs and insulin intensive treatment. After the blood glucose was basically stable, both groups were given intramuscular injection of 500μg mecobalamin once a day, 87.5mg of leaf extract was added into 250ml of saline intravenously once daily. Peida group was added with cilostazol 0.2g intravenously once a day for 250 days with saline 250ml intravenously once daily for 15 days. After treatment, the two groups of symptoms and signs were observed and the sensory nerve and motor nerve conduction velocity were monitored. [Results] The symptoms of both groups improved after treatment, but the effect of Peida group was more obvious. There was significant difference between the two groups (P <0.05). [Conclusion] Peida and Ginkgo biloba extract have clinical effects on diabetic peripheral neuropathy, but Peida group is better than Ginkgo biloba extract group.