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[目的]通过Meta分析综合评价甲状腺冷结节99mTc-MIBI显像诊断甲状腺癌的价值,并比较观察法与定量/半定量法的准确性。[方法]检索万方、维普、中国知网CNKI数据库中研究甲状腺冷结节99mTc-MIBI显像诊断甲状腺癌的文献,按照循证医学诊断性试验的标准筛选文献。用MetaDisc1.4软件合并纳入的试验结果,并绘制SROC曲线。[结果]观察法组纳入病例数为803例,合并灵敏度、特异度及加权SROC曲线下面积(AUC)分别为83.2%、78.2%、0.8904,定量/半定量法组纳入病例数为471例,上述各值分别为81.6%、90.0%、0.9273。[结论]甲状腺冷结节99mTc-MIBI显像对甲状腺癌的诊断具有较高价值。观察法和定量/半定量法灵敏度相接近,后者的特异度高,对甲状腺癌的诊断准确性更高。
[Objective] To evaluate the value of 99mTc-MIBI imaging in the diagnosis of thyroid cancer by Meta-analysis and to compare the accuracy of observation and quantitative / semi-quantitative methods. [Methods] The literature of 99mTc-MIBI imaging of thyroid cold nodules in the diagnosis of thyroid cancer was searched in CNKI database of Wanfang, Weipu, CNKI database, and the literature was screened according to the standards of evidence-based medical diagnostic tests. Incorporate the included test results with MetaDisc 1.4 software and plot the SROC. [Results] The number of patients included in the observation group was 803. The AUC of combined sensitivity, specificity and weighted SROC were 83.2%, 78.2% and 0.8904, respectively. The number of cases included in the quantitative / semiquantitative group was 471, The above values were 81.6%, 90.0% and 0.9273 respectively. [Conclusion] 99mTc-MIBI imaging of thyroid cold nodules is of high value in the diagnosis of thyroid cancer. Observations and quantitative / semi-quantitative sensitivity close to the latter of the high specificity, the diagnostic accuracy of thyroid cancer higher.