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目的 了解徐州市区精神分裂症患者应用抗精神病药物的现实状况,以促进药物合理应用.方法 采用回顾性调查方法随机抽取徐州精神病院与徐州市东方人民医院2016年6~8月门诊、住院诊治的精神分裂症患者的处方、病历共计300份,调查抗精神病药的应用现状.结果 本组患者单一用药率为60.7%(182/300),单一用药中居前6位的分别是利培酮、阿立哌唑、氯氮平、奥氮平、喹硫平、齐拉西酮;联合用药率为39.3%(118/300);使用频率前8位的分别是利培酮、氯氮平、阿立哌唑、喹硫平、奥氮平、齐拉西酮、氯丙嗪、奋乃静.结论 徐州市区抗精神病药的应用以单一用药为主,联合用药为辅,基本符合《中国精神分裂症防治指南》的要求,非典型抗精神病药物的应用处于主导地位,已取代典型抗精神病药物成为临床首选.“,”Objective To analyse the drug application of schizophrenic patients in Xuzhou and promote the rational use of drugs.Methods Retrospectively analyzed the 300 prescriptions,medical records of outpatients and inpatients with schizophrenia from June 2016 to August 2016 in Xuzhou Mental Hospital and Xuzhou Dongfang People′s Hospital.Investigated the application of antipsychotic status.Results The single drug rate was 60.7%(182/300).The first six were risperidone,aripiprazole,clozapine,olanzapine,quetiapine,ziprasidone.The combined rate was 39.3%(118/300),The frequency of the first eight used were risperidone,clozapine,aripiprazole,quetiapine,olanzapine,ziprasidone,chlorpromazine,perphenazine.Conclusion The medication situation of antipsychotics in Xuzhou was single drug-based,combined with drugs,supplemented,which is basically in line with “China′s schizophrenia prevention and control guidelines” requirements.The application of atypical antipsychotic drugs is at the forefront,which has replaced the typical antipsychotic drugs to become the clinical preferred.