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多囊卵巢综合征(PCOS)是妇科及生殖内分泌临床的一种常见疾病,可能是一些内分泌疾病的终点。常见主诉为多毛、肥胖、月经失调(主要是月经稀发)及不育,无排卵常见,经常需要用诱发排卵药物治疗其不育症。 PCOS患者雄激素水平升高,造成痤疮及多毛;卵巢内雄激素升高影响滤泡生成,参与了无排卵病理发生过程。虽然过量雄激素来源于卵巢,肾上腺也分泌一部分。垂体释放黄体生成激素(LH)增多,LH峰值有较大振幅。促性腺激素释放激素(GnRH)的释放过频导致LH出现脉冲,垂体敏感性增加,接受外源性GnRH时垂体促性腺激素(GTH)分泌增加,以致LH脉冲振幅增高。
Polycystic ovary syndrome (PCOS) is a common disease in gynecological and reproductive endocrinology and may be the end point of some endocrine diseases. Common complaints of hairy, obesity, menstrual disorders (mainly menstrual thin hair) and infertility, anovulation common, often require the use of ovulation induction drugs to treat their infertility. In patients with PCOS androgen levels increased, resulting in acne and hirsutism; ovarian androgen affect the formation of follicles, involved in the pathogenesis of anovulatory pathogenesis. Although excess androgens are derived from the ovary, the adrenal glands also secrete a portion. Pituitary release of luteinizing hormone (LH) increased, LH peak amplitude greater. The release of gonadotropin-releasing hormone (GnRH) over-frequency led to pulses of LH, increased pituitary sensitivity, increased secretion of pituitary gonadotropin (GTH) upon exogenous GnRH, and increased LH pulse amplitude.