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目的:观察西地那非在高原的抗低氧效果。方法:受试者为海拔3700m习服半年和海拔5380m习服2个月的男性士兵各10名,均采用口服同种胶囊的西地那非(西地那非组)和安慰剂(安慰剂组)进行自身对比踏阶负荷运动双盲实验。结果:海拔3700m西地那非组与安慰剂组比较,安静状态下SaO2显著增高(P<0.05),心率虽有降低,但无统计学意义(P>0.05);踏阶负荷运动后即刻心率显著降低,SaO2显著增高(P<0.05);台阶指数显著增高(P<0.05)。海拔5380m西地那非组与安慰剂组比较,安静状态下和踏阶负荷运动后即刻心率均显著降低,SaO2均显著增高(P<0.05);台阶指数显著增高(P<0.05)。结论:在高原口服西地那非可迅速改善低氧血症,增强运动能力。
Objective: To observe the anti-hypoxia effects of sildenafil in the plateau. METHODS: Subjects were 10 male soldiers who had been habitually served for an altitude of 3,700 m for 6 months and 5380 m for an additional 2 months. Both were treated with oral sildenafil (sildenafil) and placebo Group) self-contrast step-load exercise double-blind experiment. Results: Compared with placebo group, the SaO2 significantly increased (P <0.05) and the heart rate decreased, but there was no significant difference (P> 0.05) between the sildenafil group and the placebo group at altitude of 3700 m. The heart rate immediately after treadmill exercise (P <0.05). The step index was significantly higher (P <0.05). Compared with the placebo group, the heart rate of the sildenafil group and the placebo group at 5380 m altitude were significantly lower (P <0.05), and the step index was significantly higher (P <0.05). Conclusion: Oral sildenafil can improve hypoxemia rapidly and increase exercise capacity.