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目前急性胰腺炎(AP)的发病机制仍不清楚。一般认为:临床上,AP 20%～30%可发展为重症急性胰腺炎(SAP),其发病急,进展快,病情重,并可进展为全身炎症反应综合征(SIRS),死亡率高,约为40%左右。MODS 是其主要的死因。根据其临床经过大致可分为:SAP 早期(SIRS 期)及 SAP 后期(感染并发症期)。SAP 早期(SIRS 期)是其第一个死亡高峰期,此时的治疗以器官功能维护为主轴,包括液体复苏,SIRS 调控,营养支持,特殊类型 SAP 救治等诸多方面。SAP 后期主要在 SAP 早期治疗基础上,进行针对胰腺坏死、感染、出血、消化道瘘等严重并发症的治疗。随着 SIRS 阳性指标数的增加,MODS
The pathogenesis of acute pancreatitis (AP) is still unclear. It is generally believed that clinically, AP 20% -30% can develop severe acute pancreatitis (SAP), its onset is acute, rapid progress, severe illness and progression to systemic inflammatory response syndrome (SIRS), high mortality, About 40% or so. MODS is its main cause of death. According to its clinical experience can be divided into: SAP early (SIRS) and SAP late (infection complications). SAP early (SIRS period) is the first peak of its death, the treatment at this time the main function of organ maintenance, including fluid resuscitation, SIRS regulation, nutritional support, special types of SAP treatment and many other aspects. The latter part of SAP is mainly based on the early treatment of SAP for the treatment of severe complications such as pancreatic necrosis, infection, hemorrhage and gastrointestinal fistula. With the increase of SIRS positive index, MODS