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例1.男患,49岁。因左大腿内侧浸润性红斑10年,近3年增大明显。病初皮损为一类圆形淡红色癍片,直径0.7cm,稍隆起皮面,有瘙痒,抓后有渗液,时好时坏并逐渐长大。近3年原皮损发展较快。查体:发育正常,营养良好。心肺正常,腹平软无包块,肝脾未及,浅表淋巴结无肿大。左大腿内侧有4.5cm×4cm的癍块,边缘清楚但不规则,表面高低不平,上有灰白色鳞屑及痂皮,强行剥离痂皮有点状渗血及湿润面。住院后行皮损切除和转移皮瓣修补术,术后半月痊愈出院。病理:表皮角化过度伴角化不全。棘层肥厚。棘细胞排列紊乱,有的胞浆增大、深染,出现多核细胞,有异常核分裂像,有的细胞呈空泡状,间有个别角化不良
Example 1. Male, 49 years old. Due to the infiltration of erythema in the left thigh for 10 years, it has increased significantly in the past 3 years. At the beginning of the disease, the skin lesions were round reddish sepals with a diameter of 0.7 cm. The skin was slightly raised and pruritus. There was exudate after grasping, and it was good and bad and gradually grew up. In the past 3 years, the original skin lesions developed rapidly. Physical examination: normal development and good nutrition. Cardiopulmonary normal, abdominal soft without mass, liver and spleen, no superficial lymph nodes. Inside the left thigh, there is a 4.5cm x 4cm lumps, with clear but irregular edges, uneven surfaces, grayscale scales and scabs, and forced peeling of the skin and a bit of oozing and moist noodles. After hospitalization, skin lesions were removed and flaps were repaired. He was discharged after half an operation. Pathology: Epidermal hyperkeratosis with parakeratosis. Acanthosis hypertrophy. The spine cells are arranged disorderly, some of the cytoplasm are enlarged and deep stained, multinucleated cells appear, there are abnormal mitoses, some cells are vacuolized, and there are individual dyskeratosis