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口腔扁平苔藓(OLP)是一种常见的口腔黏膜慢性炎性疾病,是细胞介导的自身免疫性疾病。女性好发,扁平苔藓的原发损害为扁平发亮的丘疹,粟粒至绿豆大或更大,多角形,圆形或类圆形,边界清楚,表面保留皮纹。皮损多为紫红色或紫蓝色,也可为暗红、红褐、污灰色或正常皮色。WHO认为口腔扁平苔藓是潜在的恶性疾病[1],其癌变机制目前尚不清楚。本文就近年来国外关于口腔扁平苔藓癌变的致病因素及药物治疗方面的进展进行研究。
Oral lichen planus (OLP) is a common chronic inflammatory disease of the oral mucosa that is a cell-mediated autoimmune disease. In women, hair loss is a flat, shiny papule. Miliary grains are larger or larger than mung beans, polygonal, round or oval with clear boundaries and dermatoglyphics on the surface. Skin lesions are mostly purple or purple blue, but also dark red, reddish brown, dirty gray or normal skin color. WHO believes that oral lichen planus is a potential malignant disease [1], the mechanism of carcinogenesis is not yet clear. In this paper, foreign countries in recent years on the oral lichen planus cancer risk factors and drug treatment progress.