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作者综合描述了分子流行病学基本概念的主要内容与传统流行病学的差异。阐明：１．分子流行病学是分子生物学与流行病学相结合的边缘科学；２．化学致癌物在体内的生成量及其与生物大分子结合的生物有效量与癌症发生有关；３．染色体异常综合症是癌症早期的生物效应；癌基因激活，抗癌基因失活是被启动了的细胞恶性转化所必须的；４．先天和后天获得的宿主因素可影响人体对致癌剂的易感性；５．建立生物样品库，进行前瞻队列研究可提供连续性观察结果及癌前癌后比较，为因果关系的时间顺序提供有效的依据
The author comprehensively described the main content of molecular epidemiology and the differences between traditional epidemiology. Explain: 1. Molecular epidemiology is an edge science combining molecular biology with epidemiology; 2. The amount of chemical carcinogen produced in vivo and its biologically effective amount in combination with biological macromolecules are related to the occurrence of cancer; 3. Chromosome abnormality syndrome is the biological effect in the early stage of cancer; oncogene activation, inactivation of anticancer genes is necessary for the malignant transformation of the activated cells; 4. Innate and acquired host factors can affect human susceptibility to carcinogens; 5. Establishing a biological sample bank for conducting a prospective cohort study provides continuous observations and post-cancerous cancer comparisons, providing an effective basis for the time sequence of causality