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目的探讨分析血清纤维连接蛋白检测在肝病中的临床意义。方法 152例肝病患者作为观察组,49例健康体检者作为对照组,对比两组血清纤维连接蛋白水平,分析观察组中血清纤维连接蛋白与谷丙转氨酶(ALT)、谷草转氨酶(AST)水平的相关性。结果观察组中急性肝炎患者血清纤维连接蛋白水平(0.375±0.022)mg/L高于对照组(0.215±0.020)mg/L;重度慢性肝炎、重症肝炎和肝硬化患者血清纤维连接蛋白水平均低于对照组和急性肝炎患者,差异均具有统计学意义(P<0.05)。急性肝炎患者血清纤维连接蛋白水平与ALT和AST呈正相关(r=0.566、0.486,P<0.05),重度慢性肝炎、重症肝炎和肝硬化患者血清纤维连接蛋白水平与ALT和AST呈负相关(r=0.522、-0.569、-0.448,-0.603、-0.468、-0.554,P<0.05)。结论血清纤维连接蛋白水平能够反映重度慢性肝炎、重症肝炎和肝硬化患者肝脏病变的严重程度,对肝病患者的病情判断和预后估计具有一定的参考价值。
Objective To investigate the clinical significance of detecting serum fibronectin in liver disease. Methods Fifty-two patients with liver disease were selected as the observation group and 49 healthy subjects as control group. The levels of serum fibronectin in the two groups were compared. The levels of serum fibronectin, alanine aminotransferase (ALT) and aspartate aminotransferase (AST) Correlation. Results The level of serum fibronectin (0.375 ± 0.022) mg / L in patients with acute hepatitis in the observation group was significantly higher than that in the control group (0.215 ± 0.020) mg / L; the levels of serum fibronectin were lower in patients with severe chronic hepatitis, severe hepatitis and cirrhosis In the control group and acute hepatitis patients, the differences were statistically significant (P <0.05). Serum fibronectin levels were positively correlated with ALT and AST in patients with acute hepatitis (r = 0.566,0.486, P <0.05). Serum fibronectin levels in patients with severe chronic hepatitis, severe hepatitis and cirrhosis were negatively correlated with ALT and AST (r = 0.522, -0.569, -0.448, -0.603, -0.468, -0.554, P <0.05). Conclusions Serum fibronectin level can reflect the severity of liver disease in patients with severe chronic hepatitis, severe hepatitis and cirrhosis, and has certain reference value for the judgment of disease and prognosis of patients with liver disease.