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卡马西平(CBZ)单剂应用吸收较慢,数小时后达峰浓度,且波动较大,长期治疗或与其他抗癫痫药同用时能诱导自身代谢。有明显诱导代谢者 CBZ 每日2次服用,于服药间其血浓度有明显的波动。在三叉神经痛的治疗中已证实 CBZ 血浓度的昼夜波动与治疗效应密切相关。有研究表明癫痫病人达血浓度峰值时常伴间歇性副作用,如复视、头晕及镇静,增加
Carbamazepine (CBZ) single-dose application slow absorption, peak concentration after several hours, and volatile, long-term treatment or with other antiepileptic drugs can induce their own metabolism. There is a clear induction of metabolism CBZ taken 2 times daily, in the medication between the blood concentration there is a clear fluctuation. Day and night fluctuations in blood concentrations of CBZ have been shown to be closely associated with treatment effects in the management of trigeminal neuralgia. Studies have shown that patients with epilepsy peak blood concentration often accompanied by intermittent side effects, such as diplopia, dizziness and sedation, increased