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1例66岁女性因高脂血症服用脂必妥（0.35 g，3次/d）。服药4 d后出现三角肌酸痛、无力；服药25 d时出现全身酸痛、乏力、上下楼梯困难；服药4周时肌酸激酶（ CK）>6400 U/L，肌酸激酶同工酶（ CK-MB）150.7 U/L，乳酸脱氢酶（ LDH）611 U/L，丙氨酸转氨酶（ ALT）52 U/L，天冬氨酸转氨酶（ AST）121 U/L，尿素氮10.1 mmol/L，肌酐106μmol/L。诊断为横纹肌溶解症。因患者患有再生障碍性贫血长期服用环孢素，考虑横纹肌溶解症为脂必妥和环孢素相互作用所致。停用脂必妥，给予补液、利尿、保肝治疗。5 d后患者全身酸痛、乏力明显减轻，CK降至1170 U/L。10 d后全身酸痛、乏力等症状完全消失，CK 59 U/L，CK-MB 6.3 U/L，LDH 173 U/L，ALT 17 U/L，AST 16 U/L。“,”A 66-year-old woman received Zhibituo 0. 35 g thrice daily by mouth for hypirlipidemia. Four days after the drug administration,the patient developed ache and weakness of deltoid;25 days later, the patient developed generalized aching pain,weakness,and hard to walk up and down stairs;on 4 weeksof the drug treatment,laboratory testing showed the following values:creatine kinase( CK)>6 400 U/L, creatine kinase isoenzyme(CK-MB)of 150. 7 U/L,lactic acid dehydrogenase(LDH)611 U/L,alanine aminotransferase(ALT)52 U/L,aspartate aminotransferase(AST)121 U/L,blood urea nitrogen 10. 1 mmol/L,and creatinine 106 μmol/L. Rhabdomyolysis was diagnosed. The patient received cyclosporine for aplastic anemia for a long time. It was considered that the interaction between Zhibituo and cyclosporin induced the rhabdomyolysis. Zhibituo was stopped and fluid replacement,diuretic,and liver-protective drugs were given. Five days later,the symptoms of generalized aching pain and weakness relieved obviously and CK level decreased to 1 170 U/L. Ten days later,the symptoms of generalized aching pain and weakness disappeared completely and the levels of CK,CK-MB,LDH,ALT,and AST were 59 U/L,6. 3 U/L,173 U/L,17 U/L,and 16 U/L,respectively.