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目的:探讨缬沙坦与氢氯噻嗪联合应用于老年高血压治疗中的临床疗效及安全性。方法:选择我院于2014年3月~2016年3月期间诊治的老年高血压患者200例,用随机数字方法将其分为了研究组(100例)与对照组(100例)。对照组仅给予缬沙坦治疗,研究组同时给予缬沙坦与氢氯噻嗪治疗,对比两组的临床效果与不良反应情况。结果:研究组与对照组的总有效率分别为96.00%、88.00%,组间比较存在显著差异(Ρ<0.05);不良反应发生率分别为5.00%、9.00%,差异不明显(Ρ>0.05)。结论:缬沙坦与氢氯噻嗪联合治疗老年高血压,疗效显著、不良反应少。
Objective: To investigate the clinical efficacy and safety of valsartan combined with hydrochlorothiazide in elderly patients with hypertension. Methods: A total of 200 elderly hypertensive patients diagnosed and treated in our hospital from March 2014 to March 2016 were selected and randomly divided into study group (100 cases) and control group (100 cases). The control group was given only valsartan. The study group was treated with valsartan and hydrochlorothiazide simultaneously. The clinical effects and adverse reactions of the two groups were compared. Results: The total effective rates of the study group and the control group were 96.00% and 88.00%, respectively, with significant difference (P <0.05). The incidence of adverse reactions were 5.00% and 9.00% respectively, with no significant difference (P> 0.05 ). Conclusion: Valsartan combined with hydrochlorothiazide in the treatment of senile hypertension has significant curative effect and few adverse reactions.