论文部分内容阅读
水难溶性药物在胃肠道的水性介质中溶解缓慢,可能导致其生物利用度降低。针对此种情况,本文研究采用蔗糖酯为增溶剂,以环孢菌素为模型药物,制备易溶于水的固态口服剂型。取蔗糖单月桂酸酯100份和环孢菌素16
Poorly soluble drugs that dissolve slowly in the gastrointestinal tract in aqueous media may result in reduced bioavailability. In view of this situation, this paper studies the use of sucrose esters as a solubilizer to cyclosporin as a model drug to prepare a water-soluble solid oral dosage form. Take 100 parts of sucrose monolaurate and cyclosporine 16