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慢粒急变为巨核细胞白血病文献报告较少,现将我院一例报告如下: 患者女,36岁,1988年2月份因乏力,腹内有肿块,经检查血象、骨髓象后确诊为慢粒,给予马利兰治疗后缩小。于1988年8月不规则发热、腹块进行性增大、面黄10天入我院。体检:体温39℃,血压110/60mmHg,神志清楚;贫血貌;皮肤、粘膜无出血点;浅表淋巴结不肿大:胸骨压痛(+);肝肋未来触及;脾肋下17cm。实验室检查:血红蛋白49/L,白细胞19.6×10~9/L;血小板60×10~2/L;血片可见小巨核细胞10％。骨髓检查:2次骨穿(髂后),干抽,退针时获少许骨髓液,涂片:骨髓有核细胞增生正常偏低,分类中原巨核占30％。幼巨核占20％,胞体大小不等,多数体积较小,如淋巴细胞样大小,边缘有毛剌状突
Acute myelogenous leukemia patients report fewer reports of a case of our hospital are as follows: Female patients, 36 years old, in February 1988 due to fatigue, intra-abdominal mass, after examination of blood, bone marrow was diagnosed as CML, After treatment to reduce the Maryland. In August 1988 irregular fever, progressive increase of the abdominal mass, face yellow 10 days into our hospital. Physical examination: body temperature 39 ℃, blood pressure 110 / 60mmHg, conscious; anemic appearance; skin, mucous membrane without bleeding; superficial lymph nodes are not enlarged: chest tenderness (+); liver rib future touches; spleen rib 17cm. Laboratory tests: hemoglobin 49 / L, white blood cells 19.6 × 10 ~ 9 / L; platelets 60 × 10 ~ 2 / L; visible blood megakaryocytes 10%. Bone marrow examination: 2 times through the bone (after the iliac), dry pumping, needle back when a little bone marrow, smear: bone marrow hyperplasia of normal low, classification of megakaryons accounted for 30%. Juvenile giant nuclear accounting for 20%, ranging from the size of the soma, most of the smaller, such as lymphocyte-like size, the edge of the hair burr process