多囊卵巢综合征患者雄激素受体CAG基因长度多态性

• 作 者: Jskelinen J Korhonen S Voutilainen R 李跃萍
• 机 构: Department of Pediatrics Kuopio University Hospi tal PO Box 1777 70211 Kuopio Finland.,
• 出 处: 世界核心医学期刊文摘(妇产科学分册)
• 发表日期: 2005年10期
• 关键词: 雄激素受体 多囊卵巢综合征 基因长度 CAG 多态性 长度 教学医院 患者体重指数 片段 个体发生

Objective: To determine whether the CAG repeat length of the androgen receptor (AR) gene contributes to individual differences in the susceptibility to the development of polycystic ovary syndrome (PCOS). Design: Retrospective case- control study. Setting: University- based clinic. Patient(s): One hundred six nondiabetic women with PCOS and 112 nonhirsute fertile controls. Intervention(s): Androgen receptor gene CAG repeat length was analyzed in women with PCOS and their controls. Main Outcome Measure(s): Androgen receptor gene CAG repeat length in both groups. Result(s): The mean CAGn was 21.5 repeats in both groups (NS; t- test). Furthermore, when the CAGn lengths were divided into three categories (CAGn ≤ 18, 19- 24, ≥ 25), the distribution was similar in both groups (NS; χ 2 test). However, all five women carrying ≤ 15 CAG repeats belonged to the PCOS group. In the PCOS group, CAGn did not correlate with body mass index or serum testosterone concentration. Conclusion(s): Androgen receptor CAGn is not a major determinant of PCOS. However, it may be a significant modulator of androgen- related diseases in some individuals.

Objective: To determine whether the CAG repeat length of the androgen receptor (AR) gene contributes to individual differences in the susceptibility to the development of polycystic ovary syndrome (PCOS). Design: Retrospective case-control study. Intervention (s): Androgen receptor gene CAG repeat length was analyzed in women with PCOS and their controls. Main Outcome Measure (s): Androgen receptor gene CAG (s): One hundred six nondiabetic women with PCOS and 112 nonhirsute fertile controls. Result (s): The mean CAGn was 21.5 repeats in both groups (NS; t-test). Furthermore, when the CAGn lengths were divided into three categories (CAGn ≤ 18, 19-24, ≥ 25 However, all five women carrying ≤ 15 CAG repeats belonged to the PCOS group. In the PCOS group, CAGn did not correlate with body mass index or serum testosterone concentration Conclusion (s): And And However, it may be a major modulator of androgen-related diseases in some individuals.