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目的研究白头翁的抗癌作用。方法用不同剂量白头翁水煎剂分别给小鼠Ｓ１８０、ＨｅｐＡ肝癌、Ｅｈｒｌｉｃｈ腹水癌和Ｌｅｗｉｓ肺癌、大鼠肉瘤Ｗａｌｋｅｒ２５６动物模型连续灌胃１０天，观察其抑瘤效应，及其在体外试验中对人红白血病细胞株Ｋ５６２和大肠癌细胞株ＳＷ１１１６的作用。并观察白头翁水煎剂对小鼠ＴＮＦ形成的影响。结果白头翁水煎剂体内对５种可移植性肿瘤动物模型的ＩＤ３０分别为：２０．０ｇ／ｋｇ、２３．３ｇ／ｋｇ、４８．８ｇ／ｋｇ、１６．３ｇ／ｋｇ和１８．９ｇ／ｋｇ，体外对两株细胞的ＩＣ５０分别为２８．８ｍｇ／Ｌ和２７．８ｍｇ／Ｌ，均呈量效关系，并且能促进小鼠ＴＮＦ的形成。结论白头翁水煎剂在实验动物体内外均具有抗肿瘤作用，对肿瘤细胞的直接杀伤可能是其主要抗瘤机制，诱导ＴＮＦ的形成可能与其体内抗瘤作用亦有关。
Objective To study the anticancer effect of Pulsatilla chinensis. Methods Different doses of Pulsatilla decoction were given to mice S180, HepA liver cancer, Ehrlich ascites carcinoma, Lewis lung cancer, and Ratker256 animal model of sarcoma for 10 consecutive days. The antitumor effect was observed, and the effect was observed in vitro. Effects of Erythroleukemia Cell Line K562 and Colon Cancer Cell Line SW1116 . Observe the effect of Pulsatillae decoction on the formation of TNF in mice. Results The ID30 of Pulsatilla decoction in vivo for 5 kinds of transplantable tumor animal models were: 20.0g/kg, 23.3g/kg, 48.8g/kg, 16.3g/kg and 18.9g/kg, respectively. The IC50 of the two cells in vitro was 28.8 mg/L and 27.8 mg/L, respectively, both in a dose-effect relationship, and could promote the formation of TNF in mice. Conclusion Pulsatilla decoction has anti-tumor effect both in vitro and in vivo, and direct killing of tumor cells may be the main anti-tumor mechanism. The formation of TNF may be related to its anti-tumor effect in vivo.