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【目的】探讨吸入布地奈德治疗儿童呼吸道合胞病毒(respiratory syncytial virus,RSV)毛细支气管炎及感染后气道炎症的效果与可能发生机制。【方法】将确诊RSV毛细支气管炎120名患儿随机分成雾化组和常规组,记录比较急性期和恢复期喘息持续天数、住院天数及喘息再发例数;检测比较急性期与恢复期血清嗜酸粒细胞阳离子蛋白(eo-sinophil cationic protein,ECP)、IL-6、IL-8、IL-10结果,进行统计学分析。【结果】两组比较喘息持续天数、住院天数及喘息再发例数有统计学意义(P均<0.05);ECP、IL-6、IL-8值在急性期高于恢复期(P<0.05),IL-10急性期低于恢复期(P<0.05),对比恢复期上述检测指标在雾化组和常规组变化,差异有统计学意义(P<0.05)。【结论】吸入布地奈德治疗RSV感染毛细支气管炎效果明显,防治RSV感染后气道炎症有一定疗效。
【Objective】 To investigate the efficacy and possible mechanism of inhaled budesonide in the treatment of respiratory syncytial virus (RSV) bronchiolitis and post-infection airway inflammation in children. 【Methods】 One hundred and twenty children diagnosed with RSV bronchiolitis were randomly divided into atomization group and routine group. The duration of asthma and hospital stay and the number of recurrent wheezing were recorded and compared. The serum levels of acute and convalescent sera Eosinophil cationic protein (ECP), IL-6, IL-8, IL-10 results were statistically analyzed. 【Results】 The days of wheezing, days of hospitalization and recurrent wheeze were statistically significant (P <0.05). The levels of ECP, IL-6 and IL-8 in acute stage were higher than those in recovery stage (P <0.05) ), The acute phase of IL-10 was lower than that of convalescent phase (P <0.05). There was significant difference between the two groups (P <0.05). 【Conclusion】 Budesonide is effective in treating bronchiolitis with RSV infection and has certain curative effect in preventing airway inflammation after RSV infection.