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目的 镉的雌性性腺生殖毒性研究颇少见。本文通过亚慢性镉染毒，观察了镉对大鼠的雌性性腺毒性。方法 随机将动物分四组，染镉剂量分别为１ 、０－５ 、０－２５ 和０ ｍｇ／ｋｇ 体重。腹腔注射染毒，每日一次，每周５ 天，连续６ 周。结果 镉染毒各剂量组大鼠卵巢镉含量均显著高于对照组；高、中剂量染毒组大鼠动情周期均比对照组显著延长；高、中剂量染毒组大鼠闭锁卵泡构成比显著高于对照组。结论 卵巢同肾脏一样，也是镉的重要的靶器官之一。镉的雌性性腺生殖毒性可表现为动情周期的明显延长，卵巢细胞生长发育过程的明显障碍
The purpose of female genital gland toxicity of cadmium quite rare. In this paper, subchronic cadmium exposure to cadmium toxicity observed in rats. Methods The animals were randomly divided into four groups and the cadmium doses were 1, 0-5, 0-25 and 0 mg / kg body weight, respectively. Intraperitoneal injection of poisoning, once daily, 5 days a week for 6 weeks. Results The levels of cadmium in ovaries of cadmium exposure groups were significantly higher than those in control groups. The estrous cycle of high and middle dose groups were significantly longer than that of control group. The ratio of atresia follicles in high and middle dose groups Significantly higher than the control group. Conclusions The ovary, like the kidneys, is also one of the important target organs for cadmium. Cadmium female gonad reproductive toxicity can be expressed as significantly prolonged estrous cycle, ovarian cell growth and development of the obvious obstacles