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甲孕酮醋酸酯(DMPA)是每隔三个月注射一次的一种有效的避孕针剂。这种避孕针最常见的副作用是闭经,但许多用药者还经常患有经间出血或经期延长,为克服这种不规则出血,早先服用雌激素(例如雌二醇,每天50μg,每月共服7—10天),通过引起撤退性出血来解决。其后应用炔雌醇环戊醚。这种雌激素能储存于用者体内脂肪中,并能在体内缓慢释放。为认识这种雌激素在连续应用后能否确实减少这种副作用,作用进行了试验并报道了研究结果。在研究的设计上,作用采用了双盲试验
Medroxyprogesterone acetate (DMPA) is a potent contraceptive injections every three months. The most common side effect of such contraceptives is amenorrhea, but many people often suffer from interstitial bleeding or prolonged menstrual periods. To overcome this irregular bleeding, previous administration of estrogen (eg, estradiol, 50 μg daily for a total of Service 7-10 days), by causing withdrawal bleeding to solve. Ethinyl estradiol cyclopentyl ether is applied thereafter. This estrogen can be stored in the body fat, and can be slowly released in the body. In order to know whether this estrogen can reduce this side effect after continuous application, the effect was tested and the results reported. In the design of the study, the effect was double-blind